If a drug is metabolized in the GI tract to an inactive metabolite, what is the effect on absorption and pharmacologic action?

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Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

If a drug is metabolized in the GI tract to an inactive metabolite, what is the effect on absorption and pharmacologic action?

Explanation:
GI tract metabolism can inactivate a drug before it reaches the bloodstream, so the amount of active drug that gets absorbed is greatly reduced. That drop in systemic active drug means the pharmacologic effect is diminished. There can still be some action if a small portion is absorbed intact or if the drug exerts local effects in the GI tract, so the overall effect may persist to a lesser degree despite the extensive gut metabolism.

GI tract metabolism can inactivate a drug before it reaches the bloodstream, so the amount of active drug that gets absorbed is greatly reduced. That drop in systemic active drug means the pharmacologic effect is diminished. There can still be some action if a small portion is absorbed intact or if the drug exerts local effects in the GI tract, so the overall effect may persist to a lesser degree despite the extensive gut metabolism.

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