If the site of absorption has reached equilibrium due to a weak concentration gradient, what would the CT curve look like?

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Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

If the site of absorption has reached equilibrium due to a weak concentration gradient, what would the CT curve look like?

Explanation:
When diffusion governs absorption, the rate depends on the concentration gradient across the membrane. If that gradient is weak, the net transfer into the body is almost zero. Once equilibrium is reached at the absorption site, the net flux stops and the concentration there remains constant over time. On a concentration-time plot, this shows up as a horizontal line, since the concentration doesn’t change. The other shapes would imply ongoing changes in the absorption rate, not a steady, zero-net-flux state at equilibrium.

When diffusion governs absorption, the rate depends on the concentration gradient across the membrane. If that gradient is weak, the net transfer into the body is almost zero. Once equilibrium is reached at the absorption site, the net flux stops and the concentration there remains constant over time. On a concentration-time plot, this shows up as a horizontal line, since the concentration doesn’t change. The other shapes would imply ongoing changes in the absorption rate, not a steady, zero-net-flux state at equilibrium.

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