Inducing P-glycoprotein will cause the concentration-time curve to shift in which direction?

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Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

Inducing P-glycoprotein will cause the concentration-time curve to shift in which direction?

Explanation:
P-glycoprotein is an efflux transporter that limits absorption and promotes excretion of many drugs. When its expression is induced, more drug is pumped back into the intestinal lumen and more is cleared by biliary and renal routes. This reduces the amount of drug reaching systemic circulation, so plasma concentrations at all time points after dosing are lower. The overall exposure, including Cmax and AUC, decreases, which is reflected as a downward shift of the concentration-time profile. If P-gp were inhibited instead, you’d expect higher plasma levels and an upward shift.

P-glycoprotein is an efflux transporter that limits absorption and promotes excretion of many drugs. When its expression is induced, more drug is pumped back into the intestinal lumen and more is cleared by biliary and renal routes. This reduces the amount of drug reaching systemic circulation, so plasma concentrations at all time points after dosing are lower. The overall exposure, including Cmax and AUC, decreases, which is reflected as a downward shift of the concentration-time profile. If P-gp were inhibited instead, you’d expect higher plasma levels and an upward shift.

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