Induction of P-glycoprotein will shift the concentration-time curve in which direction?

Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

Induction of P-glycoprotein will shift the concentration-time curve in which direction?

P-glycoprotein acts as an intestinal efflux transporter, pumping drugs back into the lumen and reducing their absorption. When P-glycoprotein is induced, more transporter protein is present, so more drug is expelled during absorption and a smaller amount reaches the systemic circulation. This lowers plasma concentrations at all time points, yielding a downward shift of the concentration-time curve. You’ll typically see a lower Cmax and often a reduced AUC, reflecting diminished overall exposure. In contrast, increasing absorption or blocking efflux would cause an upward or unchanged curve, respectively, which is not what induction does.

P-glycoprotein acts as an intestinal efflux transporter, pumping drugs back into the lumen and reducing their absorption. When P-glycoprotein is induced, more transporter protein is present, so more drug is expelled during absorption and a smaller amount reaches the systemic circulation. This lowers plasma concentrations at all time points, yielding a downward shift of the concentration-time curve. You’ll typically see a lower Cmax and often a reduced AUC, reflecting diminished overall exposure. In contrast, increasing absorption or blocking efflux would cause an upward or unchanged curve, respectively, which is not what induction does.

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