Inhibition of P-glycoprotein (P-gp) would result in which effect on the absorption of a coadministered drug?

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Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

Inhibition of P-glycoprotein (P-gp) would result in which effect on the absorption of a coadministered drug?

Explanation:
P-glycoprotein acts as an efflux transporter in the intestinal lining, pumping drugs back into the gut and reducing their oral absorption. When P-gp is inhibited, this pumping back is diminished, allowing more of the drug to cross into the bloodstream. So, a coadministered drug that is a P-gp substrate would have increased intestinal absorption and higher systemic exposure. This effect is about absorption, not metabolism, which is why increased metabolism would not explain the change.

P-glycoprotein acts as an efflux transporter in the intestinal lining, pumping drugs back into the gut and reducing their oral absorption. When P-gp is inhibited, this pumping back is diminished, allowing more of the drug to cross into the bloodstream. So, a coadministered drug that is a P-gp substrate would have increased intestinal absorption and higher systemic exposure. This effect is about absorption, not metabolism, which is why increased metabolism would not explain the change.

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