Inhibition of P-gp will lead to what in the absorption of other drugs?

• A. Less absorption
• B. More absorption
• C. Greater duration
• D. Shorter duration

Answer: (B)

P-glycoprotein acts as an efflux pump in the intestinal lining, pumping many drugs back into the gut and thereby limiting their absorption into the bloodstream. When P-gp is inhibited, this efflux is reduced, so a larger fraction of the drug can cross the intestinal barrier and enter systemic circulation. The immediate outcome is increased absorption, which can also raise overall exposure and potentially enhance effects or toxicity. The other options don’t reflect the direct impact of inhibiting the intestinal efflux pump on absorption: duration changes relate more to clearance and half-life rather than the initial amount absorbed.