What is the role of hyaluronidase in IM/SC injections?

Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

What is the role of hyaluronidase in IM/SC injections?

Explanation:
Hyaluronidase works by breaking down hyaluronic acid in the extracellular matrix of connective tissue. This reduces the viscosity and resistance of the tissue around the injection site, allowing injected fluid to diffuse more widely. Because the tissue becomes more permeable, the drug spreads through the connective tissue and is absorbed into the bloodstream more quickly, speeding onset after intramuscular or subcutaneous administration. It does not shrink diffusion, act as a vasoconstrictor, or neutralize drug potency, so those options don’t fit.

Hyaluronidase works by breaking down hyaluronic acid in the extracellular matrix of connective tissue. This reduces the viscosity and resistance of the tissue around the injection site, allowing injected fluid to diffuse more widely. Because the tissue becomes more permeable, the drug spreads through the connective tissue and is absorbed into the bloodstream more quickly, speeding onset after intramuscular or subcutaneous administration. It does not shrink diffusion, act as a vasoconstrictor, or neutralize drug potency, so those options don’t fit.

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