Which drugs are known to complex with calcium and stay in bone/teeth?

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Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Prepare with flashcards and multiple-choice questions, each providing hints and explanations. Get ready for your pharmacy exam!

Multiple Choice

Which drugs are known to complex with calcium and stay in bone/teeth?

Explanation:
The key concept here is that some drugs can chelate calcium and become incorporated into mineralizing tissues like bone and teeth. Tetracyclines have chemical groups that readily bind Ca2+ and other divalent cations, forming stable drug–calcium complexes. During tooth and bone formation, these complexes become incorporated into hydroxyapatite, leading to intrinsic staining of teeth and potential effects on growing bones. This is why tetracyclines are avoided in young children and during pregnancy. The other antibiotics listed do not form suchCa2+-dependent deposits in teeth and bone, so they don’t cause this characteristic staining or tissue retention.

The key concept here is that some drugs can chelate calcium and become incorporated into mineralizing tissues like bone and teeth. Tetracyclines have chemical groups that readily bind Ca2+ and other divalent cations, forming stable drug–calcium complexes. During tooth and bone formation, these complexes become incorporated into hydroxyapatite, leading to intrinsic staining of teeth and potential effects on growing bones. This is why tetracyclines are avoided in young children and during pregnancy. The other antibiotics listed do not form suchCa2+-dependent deposits in teeth and bone, so they don’t cause this characteristic staining or tissue retention.

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